These papers collectively suggest that the common disease-common variant hypothesis may be less relevant to schizophrenia than rare variants with highly penetrant effects [25]. However it should be noted that, to date, no WGA SNP study has been well powered to detect effects of common SNPs, since they have either been performed using pooled DNA, ethnically heterogeneous samples or small samples sizes, so it is not yet possible even to rule out reasonably large effects of common SNPs in schizophrenia. Additionally, despite these strong suggestions of a role for rare highly penetrant CNVs, there has been no test of whether any common CNVs also contribute to the risk of schizophrenia.
