We also found enrichment for heritability of Parkinson disease (PD) (enrichment fold = 1.6, FDR = 0.025) in the DLPFC, accounting for 27% of disease heritability (Supplementary Fig. 30). This enrichment, however, was primarily driven by DEGs that were increased with EA proportion (DEG: enrichment fold = 1.9, FDR = 0.032; protein-coding: enrichment fold = 2.3, FDR = 0.038; Fig. 6), but not AA proportion (enrichment fold = 1.3, P = 0.23). Cell type enrichment analysis showed a similar pattern of enrichment for microglia, astrocytes and OPCs (Supplementary Fig. 10). Interestingly, we also found ancestry-associated glial cell subtypes (that is, astrocyte (AST7) and oligodendrocyte (OPC1) lineage) significantly enriched for PD heritability (enrichment fold > 2.0, FDR < 0.01; Supplementary Fig. 32), suggesting a potential role for specific glial subtypes in the pathogenesis of PD.
