Specifically, we found enrichment for heritability of ischemic stroke (enrichment fold = 1.5, FDR = 0.009) for ancestry-associated DEGs in the DLPFC, accounting for 26% of total heritability (Supplementary Fig. 30). This enrichment was mainly driven by protein-coding DEGs associated with an increase in AA proportion (DEGs: enrichment fold = 1.7, FDR = 0.013; protein-coding: enrichment fold = 2.1, FDR = 0.011), but not in EA (all DEGs: enrichment fold = 1.2, P = 0.2). Moreover, our cell type enrichment analysis showed that the DEGs associated with increased AA proportion were enriched for vascular smooth muscle cells, endothelial cells and pericytes (Supplementary Fig. 10), all of which may contribute to the vascular pathology implicated in stroke.
