As expected, patients with mTLE showed decreased grey matter volume of the ROIs situated in the affected medial temporal lobe, including the hippocampal formation and parahippocampal cortex in comparison to healthy controls (GMV-PLS, CTL and left mTLE, p = 0.005; CTL and right mTLE, p = 0.002, see Fig. 1A, Table S1 for BSRs and Fig. S1 for a general description of the DMN in controls and patients with mTLE). Additionally, patients with left mTLE also had decreased grey matter volume in the ROI situated in the left lateral temporal cortex and patients with right mTLE showed decreased grey matter volume in the ROI situated in the right temporal pole. There was no ROI that showed greater grey matter volume in patients than controls. Consistent with previous studies examining grey matter volume in mTLE (Keller and Roberts, 2008), these results indicate that mTLE is associated with grey matter volume loss primarily, though not exclusively, within the medial and lateral aspect of the affected temporal lobes.
