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Chunk #22 — Results — Changes in gene expression in the ACB-shell

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Changes in gene expression in regions of the extended amygdala of alcohol-preferring rats after binge-like alcohol drinking.
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Setting the maximum FDR at 0.25 in an analysis that combined data from the 3 time points, there were 748 total probe sets that were significantly different in the ACB-shell between the water and ethanol groups, representing 276 unique named genes and 472 ESTs (Table 1). There were approximately 3.6-fold more named genes that had higher expression than lower expression in the ethanol versus the water group (Table 1). Most of the differences between the ethanol and water groups were in the range of 1.1- to 1.2- fold, with a few as high as 1.3- to 1.7-fold (see Supplemental Table A for a complete list of significant probe sets for the ACB-shell).