Neuroimaging data were available from 906 participants who completed the ongoing DNS by 13 December 2013. The DNS assesses a wide range of behavioral, experiential, and biological phenotypes among young-adult (range 18–22 years) college students. All participants provided written informed consent in accord with Duke University guidelines and were in good general health. For completing the study, each participant received $120 remuneration. Study exclusion criteria included: (1) medical diagnoses of cancer, stroke, diabetes requiring insulin treatment, chronic kidney or liver disease, or lifetime history of psychotic symptoms; (2) use of psychotropic, glucocorticoid, or hypolipidemic medication; and/or (3) conditions affecting cerebral blood flow and metabolism (e.g. hypertension). Diagnosis of current DSM-IV Axis I and select Axis II disorders (antisocial personality disorder and borderline personality disorder) was assessed with the electronic Mini International Neuropsychiatric Interview (Sheehan et al. 1998) and Structured Clinical Interview for the DSM-IV (SCID; First et al. 1996). These disorders were not exclusionary, as the DNS seeks to establish broad variability in multiple behavioral phenotypes related to psychopathology.
