regression coefficients of the three markers with ISENS indicate higher response to ethanol (lower number of drinks needed to feel subjective effects) with the minor allele, which suggests that a common allele of these markers may increase the risk for developing AD. Although a few markers in the GAD2 gene have P-values < 0.05 for their associations with TOLMX and WDSFS, they became non-significant after adjusting for false discoveries, which may result from small effect size of those markers or insufficient power to detect their effects with the current sample size of cases.
