with alcohol phenotypes was conducted by Meyers and colleagues (Meyers et al., 2013b) using a sample of primarily male (78.3%) Israeli Jews. They found GxE interactions on indicators of heavy consumption (maximum drinks consumed in a 24-hour period) and alcohol use disorder severity (AUD criterion count), such that the effects of rs1229984 (i.e., presence vs. absence of the His allele) on alcohol outcomes was greater in individuals who had experienced adverse events during childhood than in those who had not.
