We identified 26 CpG probes that corresponded to genes with transcription start sites (TSS) within 1 Mb of rs1409568. Differences in CpG methylation were examined in CT (n=34) and TT (n=313) individuals in tissue from the frontal cortex and cerebellum(48). Only one probe (cg23182539), corresponding to TIA-1 related protein isoform 1 (TIAL1) showed nominal support for change in methylation scores as a function of genotype (Supplemental Table S9), with lower methylation scores in C allele carriers (β = −0.56, p = 0.0017; Wilcoxon p = 0.005). However, methylation change in this gene was not significant after Bonferroni correction (26 probes x 2 regions; pcorrected = 0.00096).
