There was also evidence that rs1409568 altered the binding motif for several transcription factors that are critical during embryogenesis, including those encoded by genes that include homeodomains (e.g., HOXD8, VAX1) and those from the Pit-Oct-Unc (POU) family (e.g., POU4F1, POU4F3, POU6F2: for full list, see Supplemental Table S8). Although predictions were based on common tissue sources, several transcription factors showed brain-related expression (e.g., POU6F2).
