We determined that rs1409568 was within a chromosome 10 regulatory domain spanning 120,300,000bp – 120,790,000bp that encompassed all of the genome-wide significant SNPs. The regulatory domain included 12 genes, including 3 protein coding genes (PRLHR, CACUL1, NANOS1), 4 pseudogenes (SLC25A18P1, TOMM22P5, RP11-215A21.2, LDHAP5), and 5 non-coding genes (AL356865.1, AL356865.2, U3, RP11-498J9.2, AL15778.1). Seven of 12 genes were expressed in several brain-derived tissues (Supplementary Figure S4). RP11-215A21.1 is the gene closest to rs1409568 (1.3kb from the transcription start site), however, there is no evidence that rs1409568 regulates the expression of any gene within the regulatory domain. The T allele of rs1409568 is conserved within primates, but not between primates and rodents (Supplementary Figure S5).
