Improving understanding of how low LRs and alcohol-related stimulation relate to future alcohol problems has implications for prevention of AUDs. Using low LR as an example, this characteristic is relatively common in individuals from a wide range of socioeconomic strata, and relates to the AUD risk across the sexes and racial or ethnic groups (e.g., Hinkers et al., 2006; Schuckit and Smith 2017b; Schuckit et al., 2000, 2007). For low LR, several environmental and attitudinal attributes that partially mediate the risk for adverse alcohol-related outcomes have been identified. Two investigations have shown that these mediators could be addressed through relatively inexpensive internet-based education programs to decrease heavy drinking (e.g., Savage et al., 2015; Schuckit et al., 2016a). Similar programs might be used in high schools, the military, or industry to identify drinkers with high AUD risks through low alcohol LRs and to help them mitigate future alcohol-related problems. Similar results might be seen for measures of alcohol-related stimulation. Finding genes that contribute to lower LRs and higher alcohol stimulation as risk factors for future heavy drinking and alcohol problems could
