The gene targets of specific drugs were also enriched in genetic associations with MD, although the analysis does not infer whether the effects of these agents were more likely to be congruent or opposed to the effects of genetic risk. The identified drugs provide possible repurposing opportunities and examples included several anti-cancer therapies and the agents pregabalin (used in the management of pain and anxiety) and modafinil, which is used to treat daytime sleepiness caused by narcolepsy (Table 2; key resources table).
