Using Drug Targetor, we searched for therapeutic agents grouped according to organ and mode of action using their Anatomical Therapeutic Chemical (ATC) drug class and identified targets that were enriched in the association signals from the GWAS analysis.19 Drug Targetor harnesses drug bioactivity data to prioritize drugs and targets for a given phenotype. Replicating an earlier analysis, we found the gene targets of antidepressants (ATC class N06A) are significantly enriched (see key resources table) in our association findings. Other drug classes that were significantly enriched included antipsychotics (N05A), which include some medicines with antidepressant effects.
