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Chunk #16 — RESULTS — Tissue and cell-type enrichment analysis

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Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies.
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Furthermore, we performed cell-type enrichment analyses using a human brain single nucelli RNA sequencing dataset.18 We found enrichment of expression signals for amygdala excitatory neurons and of medial ganglionic eminence (MGE) and caudal ganglionic eminence (CGE) interneurons by both MAGMA and LDSC. MAGMA also implicated further neuronal cell clusters as well as oligodendrocyte precursors at the broader cell-type level (superclusters).