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Chunk #15 — RESULTS — Tissue and cell-type enrichment analysis

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Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies.
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Analysis at a more refined level of murine cell types further emphasized the enrichment in excitatory and inhibitory neurons in multiple brain regions (key resources table; Tables S5I–S5K). Associated cell types using both methods included midbrain (mouse atlas reference: MEGLU7, MEGLU8, MEGLU10, and MEGLU11), amygdala (TEGLU22), hippocampal (CA1 and TEG LU21), thalamic (DEGLU4), and cortical (TEGLU1, TEGLU4, TEGLU8, TEGLU8, TEGLU11, TEGLU13, and TEGLU20) excitatory neurons. We also found additional evidence for the involvement of D1/D2 midbrain and striatal medium spiny neurons (MSN2 by both methods and MSN1,3–4 by MAGMA only).