The SNP-heritability of UKB AUDIT scores (total, AUDIT-C, AUDIT-P) was calculated using a genomic restricted maximum likelihood (GREML) method implemented in Genetic Complex Trait Analysis (GCTA)(19) on a subset of 117,072 unrelated individuals using a relatedness cut-off of 0.05 and controlling for age and sex. GREML analyses were run using genotyped SNPs with a MAF greater than 0.01 to construct the GRM.
