was different from the CTR group were considered as driven by smoking. rsFNC differences were considered as driven by drinking when the DRN group was different from the CTR group. If the SAD group was different from the CTR group, or both SMK and DRN groups were different from the CTR group, the rsFNC difference was designated as driven by smoking and drinking. The rsFNC between Postcentral-3b and PCC was a special case because the SMK group showed increased anti-correlation, the DRN group decreased anti-correlation, but the SAD group exhibited no difference when compared to the CTR group. We labeled this case as protective in a separate group with one rsFNC.