Figure 2 displays the mean rsFNC matrices for CTR, SMK, DRN, and SAD groups. Compared to the CTR matrix, DRN and SAD matrices show a clear pattern of decreased rsFNC between VIS-SEN, VIS-SAL, and SEN-PRE RSN groups. The differences between rsFNC matrices of CTR and SMK groups are few and difficult to spot. The most notable difference is an anti-correlation increase between PCC and Precentral-3b RSNs in the SMK group. The ANOVA test revealed 50 rsFNCs with significant group differences after FDR correction (p < 0.05). Supplementary Figure 1 shows ANOVA tables for the aforementioned results. The histogram presented in Figure 3 summarizes the relevant information contained in the post-hoc outcomes for a cleaner presentation of the observed effects. The significant rsFNC differences were catalogued as driven by smoking and drinking, drinking, or smoking. rsFNC differences where the SMK group was different from the CTR group were considered as driven by smoking. rsFNC differences were considered as driven by drinking when the DRN group was different from the CTR group. If the SAD group was different from the CTR group,
