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Chunk #33 — Results — Genetic associations — Alcohol involvement PGS

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Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations.
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Problematic Alcohol Use (PAU; Zhou et al., 2020) PGS was associated with increased hazards for suicidal ideation onset among individuals of European ancestry (HR = 1.20, p = 9.10 × 10−4, pFDR = 0.011) but not with other phenotypes (HR = 0.94–1.29, p ⩾ 0.081). Drinks/week PGS showed no significant associations (HR = 0.92–1.18, p ⩾ 0.023, pFDR ⩾ 0.14; Figure 4; online Supplementary Table S12). No significant omnibus effects were detected between alcohol involvement PGS and EF trajectories (online Supplementary Table S13). No significant omnibus effects were detected between alcohol involvement PGS and EF trajectories (online Supplementary Table S13).