In a single targeted secondary haplotype analysis, we included the associated SNP rs7597593 with the 4 markers in the confidence interval defined block 3, containing rs1344706. We observe a further increase in association for the haplotype defined by the associated allele of rs7597593 (T) in conjunction with the TTAA haplotype associated above. This comparison provides the largest observed haplotypic frequency difference between cases and controls (5.2%), and is the only haplotypic comparison to remain significant after permutation testing (P=0.017).
