We have analyzed both basal gene expression and the effects of ethanol on gene expression in LCLs from 21 alcoholics and 21 controls. We have detected differences in gene expression between LCL from alcoholics and controls and differences caused by the ethanol exposure. Most of the effects of ethanol were modest, but highlighted pathways which have changes in many genes. We have also examined the overlap between the differences we detect in LCL gene expression and the results of expression studies in brain and with data from genome wide association studies (GWAS) to identify and prioritize promising candidate genes for association and functional studies.
