A detailed description of the genotyping is available in Meyers et al., 2013 (Meyers et al., 2013). The ADH1B-rs1229984 SNP was genotyped on the Sequenom MassArray system (Sequenom, USA) as previously described (Meyers et al., 2013). No deviation from Hardy-Weinberg equilibrium was observed (χ2=2.04, p-value=0.141). Because the effects of ADH1B-rs1229984 on Maxdrinks and AUD severity remained unchanged after adjusting for ancestry (Meyers et al., 2013), no adjustment was necessary in the present interaction analyses. 8.8% of the overall sample and 9.0% of drinkers had the AA genotype, 38.9% of the overall sample and 38.5% of drinkers had the AG genotype, and 52.3% of the overall sample and 52.5% of drinkers has the GG genotype; the minor allele (A) frequency was 28.3% in the overall sample and 28.2% in drinkers (Supplemental Table 1).
