were not significant, but were largely positive (rGSNP=0.55–1.00) with one exception (SRE and age 21 AUDIT-C, rGSNP= −0.07, n.s.). Finally, we tested whether markers implicated at 8 p-value thresholds in the meta-analysis were associated with SRE scores in two independent samples. We derived the PRS using meta-analysis SNP weights and using ALSPAC-specific weights, due to the detection of significant h2snp in ALSPAC but not S4S groups. We observed several nominally significant associations (0.01 < p < 0.05) but no systematic effects.
