Heritability estimates for each S4S ancestry group were not significantly different from 0 (h2SNP<0.001; SE=0.16–0.59; p=0.13–0.50). However, for ALSPAC, heritability was moderate (h2SNP=0.36, SE=0.14, p=0.04). Although the meta-analytic h2SNP was different from 0 (h2SNP=0.19, SE=0.10), this was clearly driven by the ALSPAC group. Because h2SNP exceeded 0 only in the ALSPAC sample, only ALSPAC-specific summary statistics (i.e., not the meta-analytic results) were uploaded to LD Hub. There were no significant genetic correlations between SRE and any of the traits assessed in LD Hub, though we note that the mean χ2 (1.005) was flagged by the program as potentially too low. Complete results are available in Supplemental Table 5. We also conducted bivariate GCTA between SRE and AUDIT-C and total scores at ages 16, 18, and 21; these analyses were limited to ALSPAC given null h2SNP estimates in S4S. Genetic correlations were not significant, but were largely positive (rGSNP=0.55–1.00) with one exception (SRE and age 21 AUDIT-C, rGSNP= −0.07, n.s.). Finally, we tested whether markers implicated at 8 p-value thresholds in the meta-analysis were associated with SRE scores in two independent
