The general pattern of differences in HRR and absolute risk of developing comorbidity for schizophrenia and SUD in the 10th compared to the middle deciles, that was observed in the European sample (Extended Data Figure 8-9 and Supplementary Tables S21A and S22A) was also reflected in SZ-SUM-PRS and SUD-SUM-PRS of the ancestry outliers (See Supplementary Figure S28-3 and S28-4, and Supplementary Tables S28C and S28D). Notably, there was a tendency for a higher risk of developing SUD among depression cases inlOth decile compared to the middle deciles of the BP-PRS, SU-PRS and SUD-PRS, and less clear for the DEP-PRS, ANX-PRS and SZ-PRS (Supplementary Figure S28-4 and Table S28D). Regarding risk of comorbidity for anxiety and transitioning into bipolar disorder, the differences between 10th and middle deciles observed in the European sample (Extended Data Figure 6-7 and Supplementary Table S19A and S20A) was, however, not clearly reflected in the ancestry outliers (Supplementary Figure S28-1 – S28-2 and Supplementary Table S28A and S28B).
