as significantly observed in the European sample (Extended Data Figure 4, Supplementary Table S18G), was also observed in the sample of ancestry outliers, while the difference appeared to be opposite for the BP-PRS (Supplementary Figure S27C and Table S27C). The direction of differences significantly observed in the European sample, with increased PRS among depression cases with SUD compared to cases without (Extended Data Figure 5, Supplementary Table S18J), was reproduced in the ancestry outlier sample except for the Neuroticism-PRS (Supplementary Figure S27D and Table S27D).
