European ancestry sample (Supplementary Figure S17-1) were not reproduced in the ancestry outliers (Supplementary Figure S26). Regarding psychiatric comorbidity among depression cases a similar pattern of increased load of ANX-PRS, SZ-PRS and Neuroticism-PRS among depression cases with comorbidity for anxiety was observed in the European ancestry (Extended Data Figure 2, Supplementary Table S18A) sample and in the ancestry outlier sample, although non-significant in the latter except for Neuroticism-PRS (Supplementary Figure S27A and Table S27A). For depression cases with/without bipolar disorder, the same direction of differences observed significantly in the European sample (Extended Data Figure 3, Supplementary TableS18D), was observed for BP-PRS and SZ-PRS in the sample of ancestry outliers, but only significantly so for the BP-PRS (P=0.013, Supplementary Figure S27B and Table S27B). The direction of differences was not reproduced for the DEP-PRS and ASD-PRS. Regarding comorbidity with schizophrenia, the same direction of differences in DEP-PRS, SZ-PRS, ADHD-PRS, ASD-PRS, Neuroticism-PRS, SU-PRS and SUD-PRS, among depression cases with / without schizophrenia, as significantly observed in the European sample (Extended Data Figure 4, Supplementary Table S18G), was also observed in the sample of ancestry outliers, while the difference appeared to be opposite for the BP-PRS (Supplementary Figure S27C and Table S27C). The
