We also used FUMA to perform tissue expression analyses on data available through their website, by testing whether the identified genetic associations for both the primary and narrow depression phenotype definitions were enriched regarding transcriptome profiles of human tissues using summary statistics based on all SNPs. Finally, we used FUMA to perform cell-type enrichment analyses48 based the depression GWAS summary statistics. We use MAGMA gene-property analysis to test cell type specificity of the depression phenotype using GWAS summary statistics. MAGMA gene-property analysis with scRNA-seq: The gene-property analysis aims to test for relationships between cell specific gene expression profiles and disease-gene associations. In all the above-mentioned analyses implemented in FUMA default settings were applied.
