In H4IIE hepatocytes GSTA2 gene is induced by PPARγ activator and 9-cis-retinoic acid. The TZD PPARγ agonists, troglitazone, rosiglitazone, and pioglitazone, in combination with retinoic acid, increase GSTA2 induction, confirming that the activation of PPARγ /RXR heterodimer contributes to GSTA2 expression [111]. Unique among the GSTs, the alpha class isoenzymes have selenium independent antiperoxidase activity [112]. It has been demonstrated that alpha class GST [113–115] plays an important role in the protection mechanisms against oxidative stress induced by lipid peroxidation.
