Prominent among the LDSC genome-wide significant findings was a cluster of modest positive correlations involving BD (rgs ranging 0.25 to 0.33) and SZ (rgs ranging 0.12 to 0.15) in conjunction with immune-related disorders involving the gastrointestinal tract (i.e., CD, PBC, UC). These findings are consistent with available epidemiological evidence indicating that the presence of one set of disorders portends increased risk for a diagnosis from the other class of disorders, though the causality and temporality of these relationships is not clearly established (Cucino & Sonnenberg 2001; Dickerson et al. 2011; Sidhom et al. 2012; Benros et al. 2013; Eaton et al. 2010; Ruth Ann Marrie et al. 2017; R. A. Marrie et al. 2017). Positive genetic inter-correlations among these phenotypes are also consistent with recent work demonstrating that the positive correlation between BD and SZ are significantly mediated by both CNS and immunologic tissues (Lu et al. 2017). Our local genetic correlation analyses were inadequately powered to detect loci relevant to most of the psychiatric-immune disorder pairs, including BD. However, comparisons with SZ yielded 97 loci that were robust to
