CNS and immunologic tissues (Lu et al. 2017). Our local genetic correlation analyses were inadequately powered to detect loci relevant to most of the psychiatric-immune disorder pairs, including BD. However, comparisons with SZ yielded 97 loci that were robust to multiple test correction, 18 of which also were shown to harbor GW hits in previous studies. In several instances, these GW hits localize near genes with functions that are pleiotropic and relevant to both brain and immune system phenotypes. For example, we identified a SZ-CD correlated locus at 4q24 (4:100678360-103221356) that contained GW hits for both SZ (putatively attributed to SLC39A8) and several autoimmune diseases (putatively attributed to NFKB1 and MANBA); others have proposed that associations at this locus may exert pleiotropic effects on a wide range of phenotypes (additionally including body mass index, serum levels of manganese, N-terminal pro-B-type natriuretic peptide, and HDL-cholesterol) through a functional variant found in European populations affecting the SLC39A8 cation transporter (Costas 2017; Li et al. 2016). A locus within 11q23.3 (11:117747110-119215476) was significantly correlated between SZ and PBC and harbors a region of GW hits for multiple autoimmune disorders attributed to PLCL2, a catalytically inactive phospholipase-like protein thought to influence intracellular signaling, calcium
