et al. 2016). A locus within 11q23.3 (11:117747110-119215476) was significantly correlated between SZ and PBC and harbors a region of GW hits for multiple autoimmune disorders attributed to PLCL2, a catalytically inactive phospholipase-like protein thought to influence intracellular signaling, calcium homeostasis, and GABA-ergic receptor trafficking in immune and neuronal cell types, among others (Murakami et al. 2017; Takenaka et al. 2003; Toyoda et al. 2015). A de-novo missense mutation affecting this gene was identified in an exome sequencing study of SZ affected individuals, though no replication appears to have been reported (Xu et al. 2011). Similarly, a correlated locus within 22q13.1 (22:39307894-40545797, highlighted yellow in Figure 2) contains GW hits for PBC, which overlaps with voltage gated calcium channel gene CACNA1I; this gene has been implicated by both GWAS and rare-variant studies of SZ (Ripke et al. 2014; Andrade et al. 2016). Another correlated locus within 11q23 (11:118579747-118743772) contained GW hits for multiple autoimmune disorders and is suspected to exert pleiotropic effects through several genes, whose functions include repression of aberrant interferon signaling (DDX6; Lumb et al. 2017), chemokine signaling between T-helper and B-cells (CXCR5; Vaeth et al. 2014; Papp et al. 2014), and enzymatic break down of microbial disaccharides
