pleiotropic effects through several genes, whose functions include repression of aberrant interferon signaling (DDX6; Lumb et al. 2017), chemokine signaling between T-helper and B-cells (CXCR5; Vaeth et al. 2014; Papp et al. 2014), and enzymatic break down of microbial disaccharides (TREH; Muller et al. 2013). Notably, functional genomic studies have identified DDX6 as a gene that is perturbed during neuronal differentiation of samples derived from individuals with schizophrenia (Maschietto et al. 2015), and as a peripheral blood marker of cerebrospinal fluid serotonin metabolite levels (Luykx et al. 2016), supporting its relevance to psychiatric phenotypes.
