Providing concrete insights about specific neurobiological disturbances in female and male offspring with parental THC exposure will have far-reaching impact for the neuroscience field given the critical role of the endocannabinoid system in early brain development, a time period now acknowledged to drive the course of psychiatric disorders expressed in adulthood. The results also emphasize the switch of ventral to dorsal striatal disturbances from adolescence to adulthood that may also have significant relevance to the age-dependent vulnerability seen with different neuropsychiatric disorders. Overall, our research highlights the important consideration that should be given for examining sex-specific effects not only related to events that occur during one’s own lifetime but even across generations.
