The presence of positive or negative waves with different magnitudes in different genotyped samples indicates that the directionality of waves reflect certain sample properties. An intuitive explanation is that the LRR is calculated using a fixed set of reference samples, so the wave pattern is a reflection of how similar a given testing sample is to the pool of reference samples. Different directions of signal deviation from population mean result in different directions of waves due to the signal normalization procedure. It is therefore interesting to test what property of DNA samples correlate with the magnitude of wavy patterns.
