A total of five SNPs and two phenotypes were examined, so the Bonferroni correction for multiple testing would be 0.05/10 = 0.005. This threshold for significance is overly conservative because of a correlation that exists between certain of these SNPs (rs684513/rs578776 r2 = 0.6). However, the goal of this study was not to discover a novel association but to disentangle the well-established association between these genes and tobacco behaviors. Thus, the nominal P-values provided should be interpreted with this in mind.
