EXTPGS explained the most variance in all SUDs across both samples except AUD diagnosis in All of Us, which was slightly better predicted by SUDPGS. In COGA, EXTPGS explained between 1.6% (CUD) and 3.3% (AUD) of the variance and SUDPGS explained .39% (OUD) and 2.9% (FTND symptoms; Supplementary Table 24). In All of Us, EXTPGS explained between 3.1% (AUD) and 7.1% (TUD) of the variance in SUD diagnosis and SUDPGS accounted for 3.1% (AUD) and 4.4% (DUD; Supplementary Table 25).
