We next compared the variance explained by the residual SUD PGS in SUDs in COGA (Figure 5a). Here, too, we saw evidence of substance-specific associations such that FTND, AUD, and CUD symptoms were most strongly associated with the PGS that corresponds to their substance (e.g., resPTUPGS was most strongly associated with FTND symptoms). In Figure 5b, we show the rates of moderate SUD across quintiles of each residual PGS, with the matched SUD phenotype and residual SUD PGS shown in a darker color. Here we see that, especially for residual-PAU and PTU PGS, the prevalence of the disorder is lowest in the lowest quintile and increases in a more linear fashion across quintiles of risk in matched relative to unmatched PGS.
