Probable mechanisms underlying the food-induced AER increase include enhanced NADH reoxidation (197) and increased ADH activity (198), as suggested by preclinical models, as well as clinical evidence indicating that protein-and lipid-rich meals increase portal liver blood flow (199). Meanwhile, the search for “sobering” products continues, with current options including ADH and catalase enzymes, though their effectiveness has shown mixed results (e.g., (200, 201)). While the specific compounds and mechanisms behind the food-induced lowering of BAC remain unclear, one conclusion is certain: drinking on an empty stomach should be avoided.
