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Chunk #64 — STAR* METHODS — QUANTIFICATION AND STATISTICAL ANALYSIS — Functional annotation and gene-mapping of genome-wide significant variants

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Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders.
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interactions (Hi-C) or expression quantitative trait loci (eQTLs). Two Hi-C datasets originated from the human brain (fetal brain Hi-C (Won et al., 2016) and adult brain Hi-C (Wang et al., 2018)) were used to map credible SNPs to remotely interacting genes as previously described (Wang et al., 2018). A colocalization analysis with the recent eQTL dataset from adult prefrontal cortices (PFC) was also used to map 146 GWS loci into their target genes (Wang et al., 2018). In the end, we obtained two sets of candidate genes, one from fetal brain (positional mapping, fetal brain Hi-C), the other from adult brain (positional mapping, adult brain Hi-C, adult brain eQTLs).