Annotation of genes surrounding sentinel variants was conducted with DAVID 6.8 beta (non-beta was 6 years old)34,35. Genes within a ±0.5Mb window of each of the 390 sentinel variants were selected, as defined by GENCODE v19 GTF61. Subsequently, those with at least one significant eQTL in tissues identified from the previous enrichment analysis were included in the final list for analysis. Functional annotation analysis was run on the Homo sapiens background with default annotations in the categories of disease, functional categories, gene ontology, pathways, and protein domains, as well as with default parameters, retaining terms with at least two assigned genes. Annotation terms meeting Benjamini-Hochberg P<0.05 (adjusting for the number of terms) were considered significant.
