Enrichment was tested at both the sentinel SNP level and locus level, conceptually similar to Nicolae et al.60. At the sentinel SNP level, the number of variants that were also eQTLs in any of the 45 tissues was counted. At the locus level, variants in high LD (r2>0.8) with any of the 367 sentinel variants were examined for overlap with eQTLs, and if at least one variant within the locus was also an eQTL, the locus was counted. Subsequently, this was repeated for 100 randomly generated sets to observe if an eQTL enrichment was visible in the GWAS set. In order to assess which of the 45 tissues were driving the enrichment, counts were also computed per tissue. For each tissue, an upper-tailed p-value for enrichment of the GWAS count was calculated with a Z-score computed using the mean and standard deviation of the null distribution for that tissue.
