In conclusion, we report here that chronic alcohol induces region-specific infiltration of IMs into the CNS and that inhibition of CCR2/5 signaling using the small molecule inhibitor CVC abrogated the infiltration of macrophages. Chronic alcohol also induced cytokine expression and microglial activation that was partially normalized by CCR2/5 inhibition. These data provide critical insights into the role of CCR2/5 signaling, IMs, and microglia in alcohol-induced neuroinflammation.
