Both therapeutic response and adverse side effects of pharmacologic treatments are modulated by genetic factors. The US Food and Drug Administration (FDA) recommends that, patients of Asian descent, be screened for specific human leukocyte antigen variants that, put, them at. elevated risk of developing Stevens-Johnson syndrome when taking carbamazepine.49 Genetic screening for those at high risk for clozapine-induced agranulocytosis may soon be possible.
