Univariate and bivariate LDSC estimates for all indicator GWAS are shown in Tables S2 and S3. The correlated three‐factor GenomicSEM model provided good fit to the genetic covariance matrices among sensation seeking, alcohol consumption, and AUD (χ 2 = 117.89, df = 12, P = 1.63 × 10−19, AIC = 149.89, CFI = 0.99, SRMR = 0.06; Figure 1A; Table S4). Alcohol consumption and AUD were strongly correlated in this model (r g = 0.58, SE = 0.03, P = 3.67 × 10−120), whereas sensation seeking was moderately correlated with both alcohol consumption (r g = 0.29, SE = 0.02, P = 4.50 × 10−53) and AUD (r g = 0.21, SE = 0.02, P = 2.04 × 10−19). Constraining correlations with the sensation seeking factor to equality suggested sensation seeking was more strongly correlated with alcohol consumption than AUD (Δχ 2 = 271.06, df = 1, P diff = 6.65 × 10−61). In follow‐up sensation seeking and alcohol consumption single factor models, loadings were large and significant, and residual variances were generally small (Table S5).
