A series of LDSC genetic correlation analyses were conducted in GenomicSEM to examine whether patterns of genetic correlations with regional cortical volume, surface area, thickness, subcortical structure volume, and resting‐state connectivity phenotypes differed across sensation seeking, alcohol consumption, and AUD. A 5% FDR correction was used to account for multiple testing within each neuroimaging phenotype set. To determine whether correlations with each neuroimaging phenotype differed across traits, χ 2 tests, using the approach described by Demange et al., 50 were used to evaluate the null hypotheses that (A) pairs of genetic correlations or (B) all correlations with each neuroimaging phenotype could be constrained to equality. Follow‐up Q trait analyses were conducted to examine heterogeneity in associations between indicator GWAS and neuroimaging phenotypes not well accounted for by latent genomic factors. 51 Similar to Q SNP analyses, associations exhibiting FDR‐significant Q trait P‐values were not interpreted.
