Genome-wide association studies (GWAS) are a powerful method to identify single nucleotide polymorphisms (SNPs) that are associated with a diagnosis. The first gene to reach genome-wide significance for psychosis was ZNF804a when SNP rs1344706 was significantly associated when schizophrenia and bipolar disorder diagnoses are combined [3]. Several follow up GWAS studies have replicated the association of rs1344706 with SZ in different populations [4], [5], [6], and several other SNPs near the ZNF804a locus have a significant association with SZ [7], [8].
