Schizophrenia (SZ) is a heritable disorder having no single gene or environmental factor that accounts for a majority of cases. An emerging hypothesis to explain SZ etiology suggests that epistatic interactions between multiple susceptibility genes all converge onto a set of biological networks important for SZ pathology [1], [2]. If SZ associated genes are closely connected to a common disease pathway, then controlling the transcription of genes within this network would be critical for proper biological function. Therefore, we hypothesize that transcription factors associated with SZ may be central to a transcriptional network that regulates the expression of other SZ associated genes.
