CSD studies in alcoholism also revealed region-specific activations and altered topographic features. In a visual category-matching task, Ji and colleagues (1999) reported suppressed activations at the left temporal-occipital areas in alcoholics during both matching and nonmatching conditions (around 250 ms). In a Go/No-Go task, Kamarajan and colleagues (2005a) found that alcoholics had lower P3 amplitudes and a more diffuse and weaker P3 source without the prefrontal sink, which was observed in the control subjects during the No-Go condition (see figure 1, panels A1 and A2). Further, Kamarajan and colleagues (2012) compared topographic patterns of ERO theta activity representing total theta power with CSD maps computed from theta amplitude data extracted within the time interval of 200 to 500 ms during the feedback of loss and gain during a single-outcome monetary gambling task, with a bet of either 10 cents or 50 cents, and found low theta power and lower CSD activations in alcoholics along with topographic differences between groups (see figure 1, panels B1 and B2).
